Also, there is an important regulatory gene called "sonic hedgehog."
As well as "tiggywinkle hedgehog."
I don't know if I'll ever stop finding that amusing.
Sir: [not sure if this link will be visible to everyone]LOL. Personally, I think that an amusing name would totally take some of the sting out of having an awful syndrome!
The choice of a gene name can have unforeseen consequences in addition to infringement of trademark ("Pokémon blocks gene name" Nature 438, 897; 2005). The quirky sense of humour that researchers display in choosing a gene name often loses much in translation when people facing serious illness or disability are told that they or their child have a mutation in a gene such as Sonic hedgehog, Slug or Pokemon.
As with the acronym CATCH22 (from 'cardiac anomaly, T-cell deficit, clefting and hypocalcaemia') for chromosome 22q11.2 microdeletions, which was abandoned because of its no-win connotations (J. Burn J. Med. Genet. 36, 737–738; 1999), researchers need to be mindful when naming genes and syndromes.
Perhaps it would be hurtful, though, when you tried explaining it to people and they snickered. Or, I mean, the diagnosis would be pretty surreal.
Doctor: (gravely) "I'm afraid you have... Pokemon syndrome."